RESULTS: The search identified 496 citations, including 7 retrospective series, and 692 patients met eligibility criteria. The use of duct-to-duct anastomosis was not associated with a significant difference in clinical outcomes, including 1-year recipient survival rates (OR 1.02; 95% CI 0.65–1.60; p=0.95), 1-year graft survival rates (OR 1.11; 95% CI 0.72–1.71; p=0.64), risk of biliary leaks (OR of 1.23; 95% confidence interval [CI] 0.59–2.59; p=0.33), risk of biliary strictures (OR 1.99; 95% CI 0.98–4.06; p=0.06),
or rate of recurrence of PSC (OR 0.94; 95% CI 0.19–4.78; p=0.94). CONCLUSION: The current evidence presented herein does not support the universal preference of Roux-en-Y choledochojejunostomy for all patients undergoing OLT for PSC, as there is no significance difference XL184 in vitro in clinical outcomes between well-selected patients who receive duct-to-duct anastomosis versus Roux-en-Y loops. Selection will continue to be made by the surgeon at time of LT with or without pre-LT cholangiography, based on donor and recipient characteristics, but barring other factors such as a diseased common bile duct, our results suggest duct-to-duct anastomosis should be preferred. Disclosures: The following people have nothing to disclose: Malcolm M. Wells, Kristopher Croome, Erin Boyce, Natasha check details Chandok [Background] Glucose storage
diseases (GSD) show growth retardation, but there are a few reports about the growth pattern and the effect of portocaval shunt (PCS) and liver transplantation (LT) for GSD patients. This study aims to analyze the change of physical growth and 2nd sexuality after PCS or/and LT in GSD type I. [Patients and Methods] We reviewed retrospectively 56 patients (M : F=38 : 18) with GSD type I
between 1975 and 2013. Among them, 13 underwent LT (at median 14 year-old, range 9–21, LT group) and 17 with PCS (10, 4–12, PCS group). Their data were compared with the normal data of CDC & WHO and the height standard deviation scores (Z-scores) and its annual differences (delta Z-score) were calculated click here and presented. And a modified delta Z-score (m-delta Z-score) was defined an annual difference between Z-score of operation group and the cross-sectional median Z-score of non-operation group. [Results] Regardless of height at birth, Z score for their height was sharply decreased to less than zero within 4 years in all patients. After operations, there was a spurt of height in the postoperative period. The median Z-score was −3.1 in LT group and −2.7 in PCS group at the time of operations. They caught up growth up to Z=−0.25 at postoperative 4 years in LT group and to Z=−0.6 at postoperative 6 years in PCS group. Delta Z-score were +0.4 and +0.6 respectively in the postoperative 1st year after LT or PCS. Then delta Z-score decreased annually.