Exclusion criteria differed between FLSs; four excluded patients with pathological fractures and four with high energetic trauma (HET). Counselling of the fracture nurse was performed by the trauma surgeon in two FLSs, by an endocrinologist in three or by a rheumatologist or general internist in one FLS. Baseline characteristics (age, sex and CRFs) were screened during the visit at the FLSs by questionnaire before their visit

to the FLS in three centres and by personal contact with the nurse in two centres. In three centres, the patient filled in the questionnaire and discussed this at the outpatient clinic, in two centres all questions were asked by the nurse. CRFs were examined in all, but recording varied between FLSs. Whether patients had a history of fracture after the age of 50 years, GS-1101 order a family history of hip fracture or used glucocorticoids was recorded in >97% of

all patients. A history of vertebral fracture was asked for in all patients in four centres and in 65% of one centre. Low body weight was recorded as a CRF in >94% of patients in four centres and in 69% of patients in one centre. A fall during the past year was asked for in >99% of patients in three centres and in 44% in one centre. In one centre, the nurse inquired into previous falls in the preceding 6 months PAK5 (data not shown). RXDX-101 clinical trial DXA examinations were performed in 83 up to >99% of patients. Criteria for laboratory examinations differed between FLSs: in all patients (n = 1), only in men (n = 1), in men younger than

65 years (n = 2), in patients with a T-score <−2.0 (n = 1), and in women depending on age and T-score (n = 2) (Table 1). The acute circumstances of trauma were specified in all FLS, but extensively in four (Table 2). Table 2 Prevalence of CRFs, falls and circumstances of trauma in all patient cohorts and according to the different FLSs   1 2 3 4 5 All RRa P valueb Age (SD) 67.5 (10.7) 69.0 (10.5) 65.6 (9.3) 65.4 (9.2) 67.0 (10.2) 66.7 (10.0)   <0.001 Sex (%)               <0.001  • Women 74.2 88.2 70.0 79.9 77.0 76.7      • Men 25.8 11.8 30.0 20.1 23.0 23.3     Fracture location (%)               <0.001  • Major 18.1 15.3 13.4 14.6 14.8 15.5      • Minor 70.3 78.5 66.3 65.5 75.9 70.1      • Hip 5.5 5.3 7.6 7.3 1.0 5.7      • Fingers/Toes 6.1 0.9 12.6 12.6 8.4 8.7      • Hip 5.5 5.3 7.6 7.3 1.0 5.7      • Humerus 13.7 12.3 9.9 11.0 14.3 12.2      • Distal radius/ulna 25.8 22.4 26.8 26.9 27.2 26.1      • Tibia/fibula 12.7 12.8 13.3 12.7 12.8 12.9      • Other 42.3 47.1 42.4 42.1 44.7 43.2     BMD (%)               <0.001  • Normal BMD 23.7 5.0 26.6 15.5 30.3 21.2      • Osteopenia 44.7 54.3 46.2 45.5 47.5 46.6      • Osteoporosis 31.6 40.7 27.2 39.0 22.2 32.