(C) 2010 Elsevier Inc. All rights reserved.”
“Background and aims: An imbalance of Nuclear Factor Kappa B (NF kappa B) and Inhibitor Kappa B (I kappa B) is involved in various human diseases including atherogenesis. We aimed to evaluate the relationship between NFKB1 and NFKBIA polymorphism and susceptibility to myocardial infarction

(MI).

Methods and results: Genotyping was performed for NFKB1 and NFKBIA gene variants in 253 subjects (86 patients affected by myocardial infarction and 167 control subjects). In 40 patients, biopsy specimens were taken from the left ventricle area of presumed ischemia for p50, p65 and I kappa B alpha quantification. The allele frequency and genotype distribution of NFKBIA BAY 80-6946 inhibitor gene polymorphism did not differ between MI and control group while control subjects had a higher D allele frequency of -94 ins/del ATTG NFKB1 polymorphism, ASP2215 compared to the MI group (P < 0.001; OR = 0.304; 95% CI = 0.177-0.522). Subjects carrying the D allele had significantly lower plasma fibrinogen and CRP (C-reactive protein) levels compared to no carriers (P < 0.05). Fibrinogen-genotype interaction was found to have a significant effect on susceptibility to myocardial infarction. Myocardial p50 (r = 0.627; P = 0.012) and p65 (r = 0.683; P = 0.005) levels significantly correlated with plasma fibrinogen

levels while subjects carrying the D allele of the NF kappa B1 gene variant had lower myocardial p50 (P = 0.007) and p65 (P = 0.009) levels compared to no carriers.

Conclusion: -94 ins/del ATTG NFKB1 gene variant GANT61 clinical trial may contribute to lower MI susceptibility via the potential reduction of activated NF kappa B which in turn is related to plasma inflammatory marker reduction. (C) 2010 Elsevier B.V. All rights reserved.”
“Iron-based nanoparticles are the forerunners in the field of nanotechnology due to their high magnetization saturation and biocompability which affords them use in a variety of applications. However, iron-based nanoparticles,

due to a high surface-to-volume ratio, suffer from oxidation and limit its practicality by lowering the magnetic moment significantly. To avoid this oxidation, the surfaces of the particles have to be passivated. One such way to accomplish this passivation is to synthesize core@shell nanoparticles that have a surface treatment of chromium or nickel. These core@shell nanoparticles have been synthesized using a reverse micelle technique. The Cr and Ni passivated iron nanoparticles were characterized by x-ray diffraction, transmission electron microscopy, vibrating sample magnetometry, and x-ray photoelectron spectroscopy to determine their phase, morphology, surface properties, and magnetization saturation. A high magnetization saturation of 160 and 165 emu/g for Cr and Ni passivated iron core@shell nanoparticles was achieved. (C) 2011 American Institute of Physics. [doi:10.1063/1.