Conflicts of interest None Appendix Table 3 Studies used to comp

Conflicts of interest None. Appendix Table 3 Studies used to compute age-standardised hip fracture incidence Country Citation Notes Argentina Morosano M, Masoni A, Sánchez A (2005) Incidence of hip fractures in the city of Rosario, Argentina. Osteoporos Int 16: 1339–1344 Supplementary information from authors Australia Crisp A, Dixon T, Jones, MK0683 in vivo Ebeling P, Cumming R (2012) Declining

incidence of osteoporotic hip fracture in Australia. Manuscript in preparation Supplementary information from Australian Institute of Health and Welfare Austria Dimai H P (2008) Personal communication Supplementary information Statistic Austria Dimai HP, Svedbom A, MX69 purchase Fahrleitner-Pammer A, et al. (2011) Epidemiology of hip fractures in Austria: evidence for a change in the secular trend. Osteoporos Int22: 685–692 Belgium Hiligsmann M, personal communication, June 2011 Update of FRAX model with more extensive data Brazil Silveira C, Medeiros M, Coelho-Filho JM et al. (2005) Incidência de fratura do quadril em area urbana do Nordeste brasileiro. Cad. Saúde Pública. 21: 907–912 Average taken of all data from Brazil Komatsu RS, Ramos LR, Szejnfeld A (2004) Incidence of proximal femur fractures in Marilia, Brazil. J Nut Health Aging. 8: 362 Shwartz AV, Kelsey JL, Maggi S et al. selleck inhibitor (1999)

International variation in the incidence of hip fractures: cross-national project on osteoporosis for the World Health Organization Program for Research on Aging. Osteoporos Inositol monophosphatase 1 Int 9: 242–253 Castro da Rocha FA, Ribeiro AR (2003) Low incidence of hip fractures in an equatorial area. Osteoporos Int 14:496–499 Canada Leslie WD, O’Donnell S, Lagacé C et al. (2010) Osteoporosis surveillance expert working group. Population-based Canadian hip

fracture rates with international comparisons. Osteoporos Int. 21: 1317–1322 Supplementary information from WB Leslie Leslie WD, Lix LM, Langsetmo L et al. (2011) Construction of a FRAX® model for the assessment of fracture probability in Canada and implications for treatment. Osteoporos Int 22: 817–827 Chile Pablo Riedemann and Oscar Neira, personal communication 4th Oct 2011 Source: Health Ministry, June 2010 China Schwartz AV, Kelsey JL, Maggi S et al. (1999) International variation in the incidence of hip fractures: cross-national project on osteoporosis for the World Health Organization Program for Research on Aging. Osteoporos Int 9: 242–253 Mean of Schwartz 1999, Ling 1996, Yan 1999 and Zhang 2000 used in FRAX model Ling X, Aimin, L, Xihe Z, Xaioshu C, Cummings SR (1996) Very low rates of hip fracture in Beijing, Peoples Republic of China. The Beijing Osteoporosis Project. Am J Epidemiol 144; 901–907 Yan L, Zhou B, Prentice A, Wang X, Golden MH (1999) Epidemiological study of hip fracture in Shenyang, People’s Republic of China.

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