Despite decades of work the medicine chest contains only one pill for the long term treatment of obesity, orlistat, a lipase inhibitor that
prevents the absorption of lipid from the gut and is itself not systemically absorbed. The central controlling system for thermogenesis has many potential intervention points. Several drugs, previously marketed, awaiting approval or in the earlier stages of development may have a thermogenic effect via activation of the sympathetic nervous system at some point in the thermoregulatory circuit and are discussed in this review. If the balance is weighted to the “”wrong”" side there is the burden of increased cardiovascular Syk inhibitor risk while a shift to the “”right”" side, if possible, will afford a thermogenic benefit that is conducive to weight loss maintenance.
This article is part of a Special Issue entitled ‘Central Control Food Intake’ (C) 2011 Elsevier Ltd. All rights reserved.”
“Episodic memory and working memory decline with advancing age. Nevertheless, large-scale population-based studies document well-preserved memory functioning in some older individuals. The influential ‘reserve’ notion holds that individual differences in brain characteristics or in the manner people process tasks allow some individuals to cope better than others with brain pathology and hence show
preserved memory performance. Selleckchem MG 132 Here, we discuss a complementary concept, that of brain maintenance (or relative lack of brain pathology), and argue that it constitutes the primary determinant of successful memory aging. We discuss evidence for brain maintenance at different levels: cellular, neurochemical,
gray- and white-matter integrity, and systems-level activation patterns. Various genetic and lifestyle factors support brain maintenance in aging and interventions may be designed to promote maintenance of brain structure and function in late life.”
“Scylla O-methylated flavonoid serrata reovirus (SsRV) is one of the most prevalent viral pathogens of the mud crab (S. serrata). This pathogen is widespread in east China and causes severe economic losses to the nation’s mud crab industry. Early detection of this pathogen is necessary for disease control and reduction of economic loss. In the present study, a reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) assay for the rapid and sensitive detection of SsRV was developed and evaluated. The LAMP reaction mix was optimized, as were the reaction temperature (62 degrees C) and the duration of the assay (60 min). The sensitivity of the RT-LAMP assay was determined to be 0.8 fg SsRV dsRNA, which was 1000-fold higher than that of a one-step reverse transcription polymerase chain reaction (RT-PCR). The RT-LAMP assay also had higher sensitivity than a one-step RT-PCR, as it identified nine more positive cases from 55 mud crabs suspected of having SsRV. No cross-reactivity was found with the DNA/RNA of other tested viruses and SsRV-negative animals.