Statistical analysis showed high levels of satisfaction for all the questions, especially those regarding the choice between laser therapy and traditional instruments (100%), choosing laser in the future (89%), and recommending it to family and friends (84%). This study may be relevant when determining the overall satisfaction of patients with this new technology.”
“Marijuana dependence is a substantial public health problem, with existing treatments showing limited efficacy. In laboratory and clinical studies,
the cannabinoid receptor 1 agonist oral 9tetrahydrocannabinol (THC; dronabinol) has been shown to decrease marijuana withdrawal but not relapse. PF-00299804 inhibitor Dronabinol has poor bioavailability, potentially contributing to its failure to decrease relapse. The synthetic THC analogue, nabilone, has better bioavailability than dronabinol. We therefore aimed to characterize nabilone’s behavioral and physiological effects across a range of acute doses in current marijuana smokers and compare these with dronabinol’s effects. Participants (4 female; 10 male) smoking marijuana 6.6 (standard
deviation=0.7) days/week completed this outpatient, within-subjects, double-blind, randomized protocol. Over seven sessions, the time-dependent subjective, cognitive LY3023414 cell line and cardiovascular effects of nabilone (2, 4, 6, 8mg), dronabinol (10, 20mg) and placebo were assessed. Nabilone (4, 6, 8mg) and dronabinol (10, 20mg) increased ratings of feeling a good effect, a strong effect and/or high’ relative to placebo; nabilone had a slower onset of peak subjective effects than dronabinol. Nabilone (6, 8mg) modestly lowered psychomotor speed relative to placebo and dronabinol. There were dose-dependent increases in heart rate after nabilone, and nabilone (2mg) and dronabinol (10mg) decreased systolic blood pressure. Thus, nabilone produced sustained, dose-related increases in positive
mood, few cognitive decrements and lawful cardiovascular alterations. It had a longer time to peak effects than dronabinol, and effects were more dose-related, suggesting improved bioavailability. Nabilone was well tolerated by marijuana smokers, supporting further testing as a potential medication P005091 concentration for marijuana dependence.”
“Parthenium hysterophorus L. or Santa Maria feverfew is a plant used in Cuba since antiquity for the treatment of several diseases. Nowadays it is still used as an antipyretic and antiparasitic agent. Parthenin, a sesquiterpene lactone, is the active secondary metabolite and the major component of the plant. In this study the development and validation of a HPLCmethod for the determination of parthenin in the powdered plant material are presented, making it possible to perform quality control on preparations containing P. hysterophorus.