The primacy of such dynamics has reached unprecedented heights in current human societies that are dominated by the power of mass media and the celebrity system. This explains that self-awareness is organized as a projective phenomenon in which the subject sees and judges him- or herself from the point of view of the other to which he or she identifies.93 This leads to a form of alienation in which the subject perceives him- or herself as being an object offered in the scopic field Inhibitors,research,lifescience,medical to the gaze

of the other.2 The extant experimental evidence demonstrates that the subject is more self-conscious when aware of being under observation.94 A massive reflection Inhibitors,research,lifescience,medical of these phenomena is the contemporary “craving” for being in front of video cameras and for reality shows. This structural alienation is all the more significant very early on in life because of the little human being’s constant psychomotor struggle to walk, act, talk, and be understood.2 While the cognitive apparatus is constructively open to alterity, its fundamental dependence vis-à-vis the web of human relationships, representations and narratives, places humans at risks Inhibitors,research,lifescience,medical of difficulties with the distinction between self and other, authenticity and fiction, in the process of the building of the identity of the self. The fear of loss, separation

distress, and the need to control others as a result are central to normal and pathological psychological development.99 The self is built on a fundamental defensive attitude (that when

gone awry may turn into full-blown paranoia and/or Inhibitors,research,lifescience,medical megalomania). The developmental condition of the self discussed here is potential ground for the psychogenesis of much psychopathology affecting the relational world and social communication.96 Conclusion It is time that the perspectives discussed above became once again central to psychiatry research Inhibitors,research,lifescience,medical and clinical practice. We advocate for their integration into empirical research on normal and pathological mental phenomena, after theoretical reflections on formalization and modeling, Resminostat and for their incorporation into research on development of treatment strategies. The goal of finding neural correlates to various variables directly or indirectly related to the psychiatric symptoms and outcome is of potential use. New drugs developed from traditional research approaches may continue to play an important role in patient care. However, strategic choices of public health policy, in terms of research financing, infrastructures, and training of clinicians would benefit from pursuing a more valid and comprehensive understanding of the structure of the mind, with its levels of RAD001 mw representation and operation, and its historical nature.