221 Similarly, adult participants who experienced a first episode of depression had exhibited elevated levels of dependent traits 2 to 3 years earlier.222 However, no differences were found with regard to dependent traits PF-4691502 between adolescents who later developed depression and those who did not develop the disorder.58 Gender might also moderate

the relationship between temperament and depression; while females with higher levels of chronic depression during young adulthood had been described Inhibitors,research,lifescience,medical as shy and withdrawn at 3 to 4 years of age, males with chronic depression exhibited higher levels of under-controlled behavior as young children.223 Cognitive vulnerability Cognitive theories of depression assert that, when confronted with stressful experiences, individuals who have negative beliefs about the self, world, and future, and those who make global, stable, and internal attributions for negative events will appraise stressors and their consequences

Inhibitors,research,lifescience,medical negatively, and therefore are more likely to become depressed than those who do not have such cognitive styles.224,225 Several types of cognitions have been proposed to be related to depression, including low selfesteem, negative automatic thoughts, dysfunctional attitudes, and cognitive distortions225; self-control226; controlrelated beliefs and self-efficacy227; negative attributional style224; and Inhibitors,research,lifescience,medical a ruminative response style.228 Cross-sectional studies with clinic and community samples

of Inhibitors,research,lifescience,medical children and adolescents have consistently shown a strong correlation between a range of negative cognitions and depression.148,229 In prospective studies, negative cognitions predicted depression, often in interaction with negative life experiences.148,230,231 Developmental theorists have suggested that negative cognitions emerge over time, and that their relationship with depression becomes stronger with Inhibitors,research,lifescience,medical dcvelopment.56,232,233 Indeed, the association between negative cognitions and depression is less robust in younger children than in older children and adolescents.56,234 If negative cognitions contribute to the development of depression, then offspring of depressed individuals should be more likely to exhibit cognitive vulnerability than children whose parents have not experienced depression. Indeed, children of depressed mothers reported lower perceived self-worth and greater negative attributional style than children of nondepressed Ketanserin mothers.235 Even though there is a concurrent and predictive relationship between negative cognitions and depression in youngsters, some have questioned whether negative cognitions are a concomitant or consequence of depression rather than part of a longitudinal chain.236,237 Future studies should examine the development of cognitive vulnerability over time, and whether it needs to be primed in children.