ICCs were identified by site code 155.1 and Angiogenesis inhibitor behavior code malignant, whereas NHLs were identified by histology codes 9591, 9670-9673, 9675,

9680-9682, 9684-9687, 9690, 9691, 9695, 9698, 9700-9702, 9709, 9719, and behavior code malignant. We defined NHL subtypes using ICD-O-FT codes specified by the World Health Organization-based classification of lymphoid neoplasms recommended by the Pathology Working Group of the International Lymphoma Epidemiology Consortium.22 The major NHL subtypes included diffuse large B-cell lymphoma (9680-9682, 9684), follicular lymphoma (9690, 9691, 9695, 9698), peripheral T-cell lymphoma (9702, 9709), small lymphocytic lymphoma and mantle cell lymphoma (9670, 9673), mycosis fungoides and Sezary’s disease (9700, 9701), Burkitt lymphoma (9687), lymphoplasmacytic lymphoma (9671), and NK/T-cell lymphoma (9719). The other NHLs were combined as one group, other NHL, in this analysis, including “NHL, not otherwise specified (NOS)” (9591, 9672, 9675, 9686) and “malignant lymphoma, lymphoblastic” (9685). Although cases with combined hepatocellular cholangiocarcinoma (CHC) are rare,

some are occasionally found. There were two cases of CHC (histology code 8180 and behavior code malignant) in our population. We did not consider them as the outcome of interest in this analysis. For primary analyses, we defined woman’s HBV carrier status by her HBsAg test results only. In the secondary analyses, women without information on HBeAg (3%; 56,076/1,782,401) were excluded. We then categorized parous Nutlin 3a women into three groups: 1) HBsAg-negative serostatus; 2) HBsAg-positive with HBeAg-negative serostatus; and 3) HBsAg-positive with HBeAg-positive serostatus. The first group was considered as noncarriers of HBV, the second group as chronic carriers with limited viral replication status, and the third group as chronic carriers with high viral replication status. The time of follow-up for each woman was calculated from the date of her last HBV

test to the date of one of the following events, as listed in descending order of priority: the date of diagnosis of any cancer, the date of death, or the date of censoring on December 31, 2001. The hazard ratio (HR) with 95% confidence interval (CI) of developing medchemexpress ICC, NHL overall, and its major subtypes for HBV seromarkers were estimated by Cox proportional regression models after adjustment for the age at the last HBV seromarker test. Follow-up time was used as the time metric in the analysis. The assumption of proportionality for the Cox analysis was tested by examining the interaction between HBV serostatus and follow-up time, and no violation of this assumption was observed. Statistical significance level was defined as a P-value of less than 0.05 by two-tailed tests. SAS statistical software v. 9.