However, adverse effects of this therapy that Depression or neuropsychiatric symptoms make it difficult to be completed. The aim of study

is to evaluate neuropsychiatric symptoms with antiviral therapy and its correlation of effects on cerebral glucose metabolism (CMRglu) in chronic hepatitis C patients. Methods: Seven patients with chronic hepatitis C undergoing antiviral therapy (Interferon and Ribavirin) were prospectively evaluated neuropsychiatric symptoms by neuropsychiatric test such as Digit symbol test(DST), Block design test (BDT), and Self-rating Depression Scale(SDS).We assessed cerebral glucose metabolism (CMRglu) using [18F] deoxyglucose positron emission tomography (FDG-PET) before and the 8th weeks of treatment and after the therapy. Results: Compare to before and 8th weeks of treatment, SDS of all patients were worsened. FAK inhibitor CMRglu of six patients were 1-24% decreased in whole of the brain region. CMRglu of one patient was increased in the all of brain regions. There were no trend of result that DST and BDT before and 8th weeks of treatment. Compare to before and after the therapy,

SDS of all three patients after the treatment were recovered within normal range. CMRglu of all of patients were 2-106% increased from 8th week of treatment in learn more whole of the brain. CMRglu of all of three patients were recovered and increased -8~73%from MCE before the treatment. Conclusion: These results suggest that antiviral therapy affects on cerebral glucose metabolism and Depression or neuropsychiatric symptoms in chronic hepatitis C patients. This depression or neuropsychiatric symptoms should be reversible. We believe that Cerebral glucose metabolism is affected by antiviral therapy and that might be reversible. It might be associated with depression or neuropsychiatric symptoms. Key Word(s): 1. antiviral therapy; 2. cerebral metabolism; 3. psychiatric symptoms; 4. FDG-PET; Presenting Author: JING LAI Additional Authors: HAI-XIA SUN, KA ZHANG, FAN ZHANG,

HONG DENG Corresponding Author: JING LAI Affiliations: Department of Infectious Diseases, The Third Affiliated Hospital,Sun Yat-Sen University; Department of Infectious Diseases, The People’s Hospital of Yangshan City Objective: HBV related acute-on-chronic liver failure (ACLF) is a clinical syndrome where acute hepatic insult manifesting as jaundice (serum total bilirubin (TBil) ≥ 5 mg/dL and coagulopathy (international normalized ratio (INR) ≥1.5), complicated within 4 weeks by ascites and/or encephalopathy in a patient with chronic HBV infection. But the correlation of hepatitis B surface antigen (HBsAg) level with HBV DNA, ill severity in hepatitis B e antigen (HBeAg) negative ACLF has been scarcely investigated.