Yield 85%, M.P. 121 °C: IR (KBr) 3600 (OH), 3455 (NH), 1600 (ArH), 1460 (C N), 1372 (CH3), 835 (C–N); 1H NMR (300 MHz DMSO), δ 3.5 (6H, s, 2 × CH3), 6.4 (5H, m, ArH), 8.41 (1H, s, NH). Yield 83%, M.P. 194 °C: IR (KBr); 3690 (OH 3504 (NH), 1630 (ArH), 1475 (C N), 1360 (CH3), 820 (C–N); 1H NMR 300 MHz DMSO), δ 3.1 (6H, s, 2 × CH3), 6.2 (5H, m, ArH), 8.21 (1H, s, NH). Yield 78%, M.P. 198 °C: IR (KBr); 3560 (OH), 3570 (NH), 1635 (ArH), 1445 (C N), 1320 (CH3), 817 (C–N), AP24534 datasheet 740 (C–Cl); 1H NMR (300MHzDMSO), δ3.21 (6H, s, 2 × CH3), 6.8 (5H, m, ArH), 8.28 (1H, s, NH). Yield 81%, M.P. 165 °C: IR (KBr); 3590 (OH), 3420 (NH), 1634 (ArH), 1445 (C N), 1355 (CH3), 730 (C–Cl),
825 (C–N); 1H NMR (300 MHz DMSO). δ 2.9 (6H, s, 2 × CH3), 5.9 (5H, m, ArH), 7.83 (1H, s, NH). Yield 77%, M.P. 116 °C: IR (KBr); 3630 (OH), 3600 (NH), 1632 (ArH), 1460 (C N), 1348 (CH3), 1500 (C–NO2), 812 (C–N); 1H
NMR (300 MHz DMSO), δ 3.8 (6H, s, 2 × CH3), 6.5 (5H, m, ArH), 8.32 (1H, s, NH). Yield 82%, M.P. 178 °C: IR (KBr); 3645 (OH), 3600 (NH), 1634 (ArH), 1490 (C N), 1372 (CH3), 1530 (C–NO2), 855 (C–N); 1H NMR (300 MHz DMSO), δ 2.8 (6H, s, 2 × CH3), 5.93 (5H, m, ArH), 8.7 (1H, s, NH). Yield 72%, M.P. 176 °C: IR (KBr); 3685 (OH), 3320 (NH), 1620 (ArH), 1422 (C N), 1320 (CH3), 1545 (C–NO2), 842 (C–N); ALK inhibitor drugs 1H NMR (300 MHz DMSO), δ 2.98 (6H, s, 2 × CH3), 6.7 (5H, m, ArH) 8.51 (1H, s, NH). 2 (3′,5′-Dimethyl-4′-ethoxy carbonyl pyrrole)-1-phenyl-isosemi-carbazide (3) (0.01 mol) was added portion wise in 6 ml conc. H2SO4 and stirred with cooling for 4 h. The mixture was poured over crushed ice and the precipitated solid was filtered, washed with water dried and crystallized for methanol. Yield 60%, M. P. 243 °C; IR (KBr); 3325 (NH), 1490 (C N), 1370 (–CH3), 1712 (COOC2H5), 844 (C–N), 1H NMR (300 MHz DMSO), δ 5.2 (1H, s, pyrrole ADP ribosylation factor NH), 1.92 (6H, s, 2 × CH3), 3.7 (5H, s, COOC2H5), 6.2 (5H, complex, m, Ar–H and 1H, NH). Yield 50%, M.P. 249 °C: IR (KBr); 3322 (NH), 1500 (C
N), 1360 (–CH3), 1700 (COOC2H5), 842(C–N): 1H NMR (300 MHz DMSO), δ 6.2 (1 H, s, pyrrole NH), 2.1 (6H, s, 2 × CH3), 3.1 (5H, s, COOC2H5), 6.7 (5H, complex, m, Ar–H and 1H, NH). Yield 40%, M.P. 255 °C: IR (KBr); 3225 (NH), 1395 (C N), 1375 (–CH3), 1730 (COOC2H5), 843 (C–N), 822 (C–N), 735 (C–Cl); 1H NMR (300 MHz DMSO), δ 5.9 (1H, s, pyrrole NH), 2.1 (6H, s, 2 × CH3), 3.2 (5H, s, COOC2H5), 6.8 (5H, complex, m, Ar–H and 1H, NH).