33% had some degree of fibrosis being 60% > grado1C, and 3 patients had cirrhosis. The fibrosis is associated with the number of features MS (p <0.05). CONCLUSIONS: NASH is common in adults with features of MS, and the risk increases with the number of traits that are suffering. Dyslipidemia is the only feature of MS predictor of NASH. Age factor has been a protector of NASH in our population. In addition, fibrosis is a common finding. Therefore, we suspect NASH in any adult with MS traits even when no prior evidence of liver. Tabla 1. -differences between NASH and non-NASH Non-NASH NASH P Age (years) 69/ 17 60, 50/ 15, 50 0, 02 Hypertension 17 (37, 0) 29 (63, 0)

1 Dyslipemia 5 (16, 7) 25 Selleck Rapamycin (83, 3) 0, 01 Diabetes 6 (35, 3) 11(64, 7) 1 Obesity 17 (36, 2) 30 (63, 8) 1 Number of features MS One Two Three Four Five 13 (44, 8) 8 (38,

1)6 (28, 6) 0 (0, 0) 0 (0, 0) 16(55, 2) 13(61, 9) 15(71, 4) 2 (100, 0) 2 (100, 0) 0, 07 see more Disclosure: The following people have nothing to disclose: Victor Aguilar-Urbano, Teresa Pereda, Juana Gonzalo-Marfn, Pedro Moreno-Mejlas, Julio Bercedo, Jose Verdugo, Francisco Moya-Donoso, Francisco Femandez-Cano, Francisco Rivas-Ruiz, Norberto Gandara-Adan, J. M. Navarro BACKGROUND/AIMS: Nonalcoholic fatty liver disease (NAFLD) is associated with a higher prevalence of insomnia and gastroesophageal reflux disease (GERD). NAFLD encompasses nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). The association of insomnia with selleck chemicals llc GERD in

NAFLD remains unknown. The present study investigated the relationships between GERD symptoms and insomnia in subjects with biopsy-proven NAFLD. Methods: One hundred twenty three patients with biopsy-proven NAFLD (median age: 59) were enrolled in this study. Insomnia was assessed by the Athens Insomnia Scale (AIS), a self-assessment psychometric instrument designed for quantifying sleep difficulty based on the ICD-10 criteria. Patients with AIS of more than 6 were considered as insomniacs. GERD symptoms were evaluated by using a frequency scale for the symptoms of GERD (FSSG). Patients with FSSG scores of more than 8 were considered as positive. Logistic regression models were used to evaluate the association of insomnia with GERD, after adjusting for potential confounders. Thirteen NAFLD patients with GERD symptoms were administrated a proton pump inhibitor (PPI), rabeprazole (RPZ) (10mg/day) for 12 weeks to investigate the effect on insomnia. Results: Overall, 62% were female, and 71% were obese. The prevalence of NAFLD with AIS> 6 and FSSG score > 8 was 28% and 25%, respectively. Liver biopsy revealed 40 NAFL and 83 NASH. There were no differences between the two groups in FSSG and AIS. Overall, AIS was positively correlated only with FSSG among clinical parameters. AIS did not correlate with histological steatosis, grade, and fibrosis. The levels of yGT, HOMA-IR, and FSSG were significantly higher in insomniacs compared to noninsomniacs.