4%) were on therapy. Conclusions: Based on this small sample of 14 clinics, adoption of the CASL Guidelines for the management of CHB has been poor at the primary care level in Canada. Physicians are frequently not screening for GHB, not testing patients, nor assessing viral replication adequately. CHIR-99021 cost When viral replication was assessed, two-thirds of patients who might require treatment were not being treated. Screening for HGG was also not well done. Education of PGPs in the management of GHB

is urgently needed, and communication between PGPs and specialists can be improved to ensure better patient management. Disclosures: Morris Sherman – Advisory Committees or Review Panels: Merck, check details Tibotec, Roche, Gilead, Celsion, Janssen; Speaking and Teaching: Gilead, Bristol Myers Squibb, Bayer Phuong Nguyen – Advisory Committees or Review Panels:

GILEAD, BMS, MERCK, PFIZER, ASTRA ZENECA, GSK, TAKEDA, BI, ELI LILLY, AMGEN, GALDERMA, NOVARTIS, ASTELLAS, ABBOTT Jean Palmart – Independent Contractor: Gilead Sciences Canada Background: Currently 4 million persons in the US have active hepatitis C infection and world- wide there may be as many as 170 million people with this infection. Most patients have never been treated and newer therapies herald the potential for wider uptake and acceptance of treatment. Primary care providers will be needed to help expand access to care, but few models of collaborative primary care hepatitis C practices exist. Methods: Retrospective

analysis of collaborative primary care clinic for evaluation and treatment of patients with chronic hepatitis C at a single VA medical center. A single half-day clinic was organized with 4 primary care MDs, two nurse practitioners, one nurse case manager, and 1-2 hepatologists. A co-located psychiatrist and one pharmacist were integrated into the clinic, and bi-monthly noon meetings were held to discuss treatment issues. Clinic productivity and outcomes related to the number of patients who initiated and completed treatment with MCE公司 direct acting antivirals (DAA) and pegylated interferon and ribavirin from July 2011 through December 2012. Results: This clinic had 1890 confirmed HGV registry patients and a total of 1690 clinic visits during this 18 month time period. Clinic capacity included 215 patient slots per month. Same week appointment access was provided. During this time 74 patients with HGV genotype 1 initiated DAA antiviral therapy. Primary care providers treated 47 patients (32% cirrhotic) vs. 27 patients treated by hepatologists (48% cirrhotic). The percentage of patients that completed 0-19 weeks, 20-28 weeks, 29-36 weeks, and greater than 36 weeks of antiviral treatment 25. 9%, 36. 2%, 10.3%, and 27. 6, respectively. Final SVR rate was 46% (33. 3% cirrhotics vs 55. 2% noncirrhotics).