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(1.0–2.35) Age Job strain m 1.47 (0.96–2.25) Age, smoking, PCI-32765 in vitro biological risk factors Kuper (2006) Swed. women lifestyle and health cohort Sweden 2+ 35,471 30–50 years 200 cases 11.2 years Stroke, morbidity and mortality Job strain f 1.2 (0.8–1.9) Age   Kuper (2006) swed. women lifestyle and health cohort Sweden 2+ 35,471 30–50 years 210 cases 11.3 years CHD, morbidity and mortality Job strain f 1.4 (0.7–2.7) age Job strain f 1.0 (0.5–1.9) Age, biological and behavioural risk factors Uchiyama (2005) Hypertension follow-up group Japan 2+ 1,615 40–65 years 38 cases 5.6 years CVD mortality Job strain f 6.66 (0.93–47.7) m 1.75 (0.49–6.29) Age Job strain f 9.05 (1.17–69.86) m 1.86 (0.51–6.75) Age, biological and behavioural learn more risk factors Fauvel (2003) France 2− 292 18–55 years 93 cases 5 years Progression to hypertension (>7 mm increase in SBP or DBP) f + m p > 0.05 No adjustment   Tsutsumi (2006) Jichi medical school Japan 2− 6,509 18–65 years 35 cases 9.4 years CVD mortality Job strain f + m 2.47 (0.81–7.51) selleck chemical Age, sex Job strain f + m 1.98 (0.59–6.7) Age, sex, occupation, community, biological and behavioural risk factors Tsutsumi (2009) Jichi medical school Japan 2− 6,553 18–65 years 147 cases 11 years Stroke morbidity and mortality Job strain f 1.25 (0.56–2.78)

m 2.62 (1.13–6.04) Age, region Job strain f 1.46 (0.63–3.38) m 2.53 (1.08–5.94) Age, area, behavioural and biological

risk factors Lee (2002) Nurses health study USA 2− 35,038 46–71 years 146 cases 4 years CHD morbidity and mortality Job strain f 0.8 (0.48–1.34) Age Job strain f 0.71 (0.42–1.19) Dichloromethane dehalogenase Age, smoking alcohol, menopausal status, biological risk factors, parental history of CVD Markovitz (2004)f CARDIA USA 2− 3,200 20–32 years 89 cases 8 years Hypertension (SBP > 160 or DBP > 95 mmHg)   Job strain f + m 2.06 (1.01–4.26) Age, BMI, baseline blood pressure aName of the cohort, if applicable bModified version of the Scottish Intercollegiate Guidelines Network (SIGN) checklist for cohort studies (Harbour and Miller 2001) c CHD coronary heart disease (myocardial infarction, angina), CVD cardiovascular disease dSignificant (p < 0.05, CI excluding 1) results in bold letters. f female, m male, n.s. not significant. Risk estimates for job strain were calculated by comparing the high-strain group with the low-strain group (exception Eaker et al.: high-strain group is the reference group). In most cases, hazard ratios or relative risks were estimated, and in case of other statistical analyses, p values or level of significance is indicated eBlood pressure, and/or lipids, and/or fibrinogen and/or BMI, and/or diabetes are considered as biological risk factors. Smoking, and/or alcohol, and/or low physical activity are considered as behavioural risk factors.