A significant interaction effect was observed between time and the group (repeated measure ANOVA) in the WOMAC total score and the WOMAC subscales scores of pain, stiffness, and function. In the placebo group, maximum improvement occurred at the 4th week and there was no significant improvement during the remaining time. In the HCQ group, maximum improvement occurred at the 8th week and lasted over the entire remaining follow-up period. There were significant Inhibitors,research,lifescience,medical differences between the two Alisertib supplier groups as regards the degree of reduction in the WOMAC total score and the WOMAC
subscales scores of pain, stiffness, and function at weeks 4, 8, 12, 16, 20, and 24 (figures 2--55). Table Inhibitors,research,lifescience,medical 2 Mean WOMAC scores over time in the studied patients Figure 2 This graph illustrates the mean changes
from baseline in the sellekchem Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score over 24 weeks of treatment in the studied patients Figure 5 This is a represntation of the mean changes from baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function score over 24 weeks of treatment in the study population Inhibitors,research,lifescience,medical Figure 3 This graph illustrates the mean changes from baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score over 24 weeks of treatment in the studied patients Figure Inhibitors,research,lifescience,medical 4 This is an illustration of the mean changes from baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) stiffness score over 24 weeks of treatment in the study population There was a statistically significant difference between the two groups vis-à-vis the average number of painkiller pills consumed during the trial (0.74 pill per day in the HCQ group and 0.96 pill in the placebo group; P=0.035). Inhibitors,research,lifescience,medical Three patients in the HCQ group discontinued the treatment due to drug side effects (skin rash in 2 and vertigo in one), whereas there were no drug side effects in the placebo group. The difference between the two groups with respect to the frequency of drug side effects
was statistically significant (P=0.001). Discussion The knee joint is commonly afflicted by osteoarthritis. As much as knee osteoarthritis is a disease of high prevalence in world AV-951 populations and is associated with high morbidity, the treatment has shown little progress in the last decades.10,11 Pharmacologic treatment categories for osteoarthritis are typically set up to designate whether drugs are symptom-relieving or disease-modifying. Nonetheless, the evidence has thus far proved insufficient as to which drugs have optimal disease-modifying properties in osteoarthritis.2 Antimalarial agents have immunomodulatory and anti-inflammatory properties, and the effectiveness of these drugs in the therapy of some rheumatic diseases has been well known in the medical literature for many years.