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“Background Erwinia amylovora is the causative agent of fire blight, a destructive, contagious disease of apple, pear, and other rosaceous plants [1]. All aerial parts of the hosts can be infected by the pathogen. E. amylovora enters its host plants through natural openings (e.g., flower nectaries or leaf stomata) and wounds [2]. Upon entry, the fire blight pathogen moves through intercellular spaces towards the xylem [3]. Typical symptoms include flower necrosis, immature fruit rot, shoot curvature (shepherd’s crook), bacterial ooze secretion, and cankers on woody tissues [1]. The most effective method to treat infected plants is pruning to remove all infected tissue. However, fire blight can infect entire orchards within a single growing season leading to devastating economic losses [4].