Eleven days after treatment, tumors were harvested for histologic and immunohistochemical analysis. Animals demonstrating complete tumor regression were rechallenged in the contralateral flank.

Results: Animals treated with subtotal RF ablation showed significant increases in tumor-specific class I and II responses to HY antigens and tumor regression. RF ablation, ITDC, and combined groups demonstrated similar FRAX597 inhibitor levels of antigen-presenting cell infiltration; all groups demonstrated greater levels of infiltration compared with untreated controls. ITDC injection also resulted in tumor regression. However,

combination therapy did not enhance tumor regression when compared with either treatment alone. Rechallenged mice in RF ablation, ITDC, and combination groups demonstrated significant tumor growth inhibition compared with controls.

Conclusion: Subtotal RF ablation treatment results in enhanced systemic antitumor T-cell immune responses and tumor regression that is associated with increased dendritic cell infiltration. ITDC injection mimics the RF ablation effect but does not increase immune responses when injected immediately after RF ablation. (c) RSNA, 2009″
“We

have studied a longitudinal polymer liquid crystal selleck compound consisting of poly(ethylene terephthalate) (PET) and p-hydroxybenzoic acid, namely PET/0.6PHB, where 0.6 is the mole fraction of the second component. The material was injection 获悉更多 molded with systematic variations of the melt and mold temperatures and injection flow rate using design of experiments

based on a Taguchi orthogonal array. Thermomechanical environment defined by local melt temperatures and shear rates and stresses imposed during processing was estimated by computer simulations of the mold-filling phase. The morphology of the moldings was characterized by optical and scanning electronic microscopy, wide- and small-angle X-ray scattering, and differential scanning calorimetry. An analysis of variance approach identified the significant processing variables and their contributions to variations of morphological parameters. The processing environment affects strongly the melt viscosity, and there is a strong thermomechanical coupling. The result is a complex multilaminated and hierarchical microstructure, whose morphological features are very sensitive to the processing conditions. Relationships between local thermomechanical variables (rather than global ones) and the morphological parameters are established. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 115: 2991-3004, 2010″
“We compared the daily rhythms of body core temperature and surface temperature in 10 Comisana ewes housed at thermoneutrality (25 degrees C) and in the cold (9 degrees C).