Extended LN dissection was performed in 98 patients (81%), with a median of 14 nodes removed (interquartile range [IQR]: 8-18). Twenty-four patients (20%) had node-positive disease (N1: 10 [8%]; N2: 14 [12%]). Eight patients (6.6%) had positive

soft tissue margins. Median follow-up was 5.5 yr (mean: 5.9; IQR: 4.2-8.2; range: 0.13-12.1). At last follow-up, 58 patients (48%) had no evidence GSK690693 in vivo of disease, 3 (2%) were alive with recurrence, 59 (49%) had died, and status was unknown in 1. Twenty-eight patients (23%) died from cancer-specific causes, 20 (17%) from unrelated causes, and 11 (9%) from unknown causes. The 10-yr actuarial OS, CSS, and RFS rates were 35%, 63%, and 54%, respectively. At last follow-up, Etomoxir OS for pT0, pTis/a, pT1, pT2, and pT3 versus pT4 was 67%, 73%, 53%, 50%, and 16% versus 0%, respectively (p = 0.02). At last follow-up, CSS for pT0, pTis/a, pT1, pT2, and pT3 versus pT4 was 100%, 91%, 74%, 77%, and 56% versus 0%, respectively (p = 0.03).\n\nConclusions: The longest oncologic outcomes following RARC and LRC for BCa reported demonstrates results similar to those reported for open RC. Continued analysis and direct randomized comparison between techniques is necessary. (C) 2013 Published by Elsevier B. V. on behalf of European Association of Urology.”
“The Essential Health Care Package (EHP) approach has been

promoted as a tool for guiding priority setting (PS) in Low Income Countries (LICs). This approach was expected to improve PS by; (i) providing credible evidence, (ii) improving efficiency, (iii) making PS more transparent, explicit GSK923295 and objective, (iv) increasing

public empowerment and accountability; and (v) improving equity. To date, there is paucity of literature discussing the degree to which the EHP approach has met these expectations. This review paper fills this gap. We demonstrate that the EHP approach has only marginally met some of the above expectations. While this has been blamed on the lack of resources and capacity to deliver the package, we argue that limited attention paid to the PS process and the context, failure to institute and strengthen the capacity of PS institutions, and lack of an inbuilt process of monitoring and evaluating the implementation of the approach, may have also contributed to the EHP’s not meeting its expectations. While we use the example of the EHP approach, this discussion is relevant to any PS approach and the proposed recommendations (if implemented), would contribute to strengthening PS in LICs. (C) 2013 Elsevier Ltd. All rights reserved.”
“A quantitative analysis of polyamines in lung cancer patient fingernails by the combination of 4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole derivatives and liquid chromatography-electrospray ionization tandem mass spectrometry is described.