First, the assumptions related to the Ralimetinib molecular weight attribution to osteoporosis in women were changed by using Quebec data on fragility fractures among 2,075 women 50 years and older (e.g., 75.7% between the ages of 50 to 59 years old to 91.8% in the group over the age of

80) [22]. Second, although we identified individuals who were hospitalized with a most responsible diagnosis code of osteoporosis but without a diagnosis of fracture ATM Kinase Inhibitor research buy or intervention code, the base case analysis excluded those individuals, as we were uncertain how to attribute the admission. In an additional sensitivity analysis, we included these cases in our cost estimates. Third, in the absence of accurate data on the reasons for admissions to long-term care facilities, the primary analysis ignored the costs associated with those individuals residing on a yearly basis in long-term care facilities due to osteoporosis. Based on an economic model developed for the Ontario Ministry of Health and Long Term Care’s Medical

Advisory Secretariat [23], it was estimated that 17% of men and 21% of women over the age of 65 were residents in long-term care facilities following an osteoporosis-related A-1210477 in vivo fracture. Finally, the last sensitivity analysis was conducted assuming that all high and low-trauma fractures were due to osteoporosis. This scenario was based on the evidence generated by Mackey et al. showing that low BMD predicts both high and low-trauma fractures [18] and that antiresorptive treatments prevent high- and low-trauma fractures [24], leading to the recommendation for using all fractures as standard outcomes in osteoporosis trials and observational studies. Results Hospitalizations, same day surgeries, Verteporfin solubility dmso and emergency room visits due to osteoporosis-related fractures

As shown in Table 2, CIHI data for all Canadian provinces except Quebec indicated that 44,707 hospitalizations were attributable to osteoporosis-related fractures in FY 2007/2008. The number of osteoporosis-related fractures in Quebec was estimated at 12,706 for a total of 57,413 hospitalizations in Canada. These hospitalizations resulted in 832,594 hospitalized days. The mean length of stay was 14.5 days [median (Q1, Q3) = 7 (1, 0.15) days]. Fractures in women accounted for approximately 70% of all hospital admissions (men—16,855; women—40,550) and hospitalized days (men—228,231; women—604,363). Among women, hip fractures accounted for half of the hospitalized days (316,607 out of 604,363). Over 70% of all fractures occurred in individuals older than 70 years with the highest number of hospitalizations observed in the 81–90 years age group (21,033 of 57,413). In addition, osteoporosis-related fractures resulted in 112,740 emergency room visits and 3,433 same day surgeries. Eighty percent of all same day surgeries were due to wrist fractures while wrist (30%), hip (23%), and other fracture sites (30%) accounted for more than 80% of all osteoporosis-related fracture visits to the ER (Fig. 1).