Here, we summarise the evidence for involvement of specific tyrosine kinases in the pathogenesis of IPF and the development of

tyrosine kinase inhibitors as treatments for IPF.”
“To date, the signal transducing adaptor molecule 2 (STAM2) was shown to harbour two ubiquitin binding domains (UBDs) known as the VHS and UIM domains, while the SH3 domain of STAM2 was reported to interact with deubiquitinating enzymes (DUBs) like UBPY and AMSH. In the present study, NMR evidences the interaction of the STAM2 SH3 domain with ubiquitin, demonstrating that SH3 constitutes the third UBD of STAM2. Furthermore, we show that a UBPY-derived peptide can outcompete ubiquitin for SH3 binding and vice versa. These results suggest that the SH3 domain Fer-1 chemical structure of STAM2 plays versatile roles in the context of ubiquitin mediated receptor sorting. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.”
“Maternal fish intake during pregnancy may influence the risk of child asthma and allergic rhinitis, yet evidence is conflicting on its association with

these outcomes. We examined the associations of maternal fish intake during MDV3100 in vivo pregnancy with child asthma and allergic rhinitis. Mothers in the Danish National Birth Cohort (n 28 936) reported their fish intake at 12 and 30 weeks of gestation. Using multivariate logistic regression, we examined the associations of fish intake with child wheeze, asthma and rhinitis assessed at several time points: ever wheeze, recurrent wheeze (>3 episodes), ever asthma and allergic rhinitis, and current asthma, assessed at 18 months (n approximately 22 000) and 7 years (n approximately 17 000) using self-report and registry data on hospitalisations and prescribed medications. Compared with consistently high fish intake during pregnancy (fish as a sandwich or hot meal >= 2-3 times/week), never eating fish was associated with a higher risk of child asthma diagnosis at 18 months (OR 1.30, 95% CI 1.05, 1.63, P = 0.02), and ever asthma

by hospitalisation (OR 1.46, 95% CI 0.99, 2.13, P = 0.05) and medication prescription (OR 1.37, 95% Dinaciclib manufacturer CI 1.10, 1.71, P = 0.01). A dose-response was present for asthma at 18 months only (P for trend 0.001). We found no associations with wheeze or recurrent wheeze at 18 months or with allergic rhinitis. The results suggest that high (v. no) maternal fish intake during pregnancy is protective against both early and ever asthma in 7-year-old children.”
“To evaluate roles of preoperative lymphoscintigraphy for sentinel lymph node biopsy in breast cancer patients.\n\nFive hundred and sixty-five consecutive breast cancer patients were prospectively randomized into groups with or without preoperative lymphoscintigraphy.\n\nIn a group with lymphoscintigraphy, 238 patients had sentinel lymph nodes spotted in lymphoscintigram.