In this regard the influence of ginseol k-g3 on other neurotransmitter systems (e.g., γ-aminobutyric acid) should be explored. Moreover, earlier studies have attributed screening assay that the memory-enhancing effects of Rg3 to neuroprotection against excitotoxicity [18]. The AD drug donepezil has also been ascribed neuroprotective effects against glutamate-induced neurotoxicity, and this mechanism coupled with enhancement of cholinergic functions has been suggested to explain donezepil-induced amelioration of cognitive

deficits [40]. Furthermore, scopolamine-induced memory impairment in mice is also associated with altered brain oxidative stress status [41]. Thus, the effects of ginseol k-g3 on oxidative stress need to be examined. In summary, we have reported here a viable and cost-effective method of Rg3 enrichment. The Rg3-enriched fraction, ginseol k-g3, significantly reversed scopolamine-induced memory impairment in mice in the passive avoidance and Morris water maze tests, signifying

a specific influence of the compound on reference or long-term memory. Moreover, we suggest that Rg3 enrichment through the ginseol k-g3 fraction enhanced the efficacy of Rg3 in scopolamine-induced memory impairment in mice, as demonstrated in the Morris water maze task. However, considering that ginseol k-g3 also contained other ginsenosides aside from Selleck PS 341 Rg3, enhanced efficacy of ginseol k-g3 may have been brought by modulatory effects exerted by other ginsenosides (e.g., Rg5 and Rk1). It is noteworthy that both Rg5 and Rk1 have been shown to protect against scopolamine-induced memory deficits in mice [18] and [42]. As stated previously, the presence of other beneficial ginsenosides in ginseol k-g3 may be

an important feature of the preparation when used as a formulation for AD. Furthermore, the mechanism underlying the reversal of scopolamine-induced amnesia by ginseol k-g3 is not yet known, but is not related to inhibition of AChE activity. Further optimization of Rg3-enriched preparations is suggested because it may aid the development of Rg3-enriched nutraceuticals with therapeutic potential for AD. Additionally, it would also be beneficial to evaluate Calpain the memory enhancing effects of ginseol k-g3 in normal animals. All authors have no conflicts of interest to declare. The authors acknowledge financial support from Sahmyook University. “
“Helicobacter pylori infection leads to gastroduodenal inflammation, peptic ulceration, and gastric carcinoma [1] and [2]. H. pylori infection is reported to include pathologic changes of the stomach, including edema and congestive surface epithelium [3]. A characteristic event in gastritis is the infiltration of the subepithelial gastric lamina propria by phagocytes, mainly neutrophils and macrophages, that produce large amounts of reactive oxygen species (ROS).