Interestingly, this angiotensin induced cerebrovascular dysregulation was attenuated in female in contrast with male mice, selleck inhibitor This sexual dimorphism of the cerebral blood vessel response to angiotensin II may well be implicated in the intercourse dierence in cognitive impairment reported in epidemiological scientific studies, On the other hand, Takeda et al. demonstrated that the ARB olmesartan ameliorates amyloid B induced impairment of functional selleckchem SB939 hyperemia evoked by whisker stimulation through a lower in oxidative pressure in brain microvessels, Just lately, Zhang et al. reported that angiotensin II increases cerebral microvasculature inammation through induction of oxidative anxiety and leads to immune endothelial interaction, resulting in enhancement of BBB permeability, There fore, angiotensin II induced oxidative worry might have a important part in dysfunction with the neurovascular unit, To the other hand, many reviews indicate the eect of angiotensin II

on astrocytes to be neuroinammation, neuronal injury and astrocyte senescence.