Only 7% of the patients displayed assay resistance to all 7 agents, while 5% were sensitive to all 7 agents. Thus, 93% of the patients were nonresistant (sensitive or IS) to at least 1 agent. Specifically, 35% were IS to at least 1 agent, and 58% were sensitive to at

least 1 agent. Of note, 18% of these tumors were resistant to carboplatin but, of those, 59% of them were nonresistant (sensitive or IS) to at least 1 other agent in the chemoresponse assay. The standard of care for first-line treatment of patients with advanced-stage EOC consists of aggressive cytoreductive surgery followed by platinum/taxane-based chemotherapy14; however, in this treatment approach, approximately 20-30% of patients will have platinum-resistant disease.15 If identified early, platinum-resistant EOC patients may benefit from alternate and/or

additional therapeutic Etoposide cell line options in first-line therapy. At NVP-BGJ398 supplier the time of recurrence, clinicians will classify patients as being platinum sensitive (EOC relapsing >6 months after the end of first-line chemotherapy) or platinum resistant (EOC relapsing within 6 months after the end of first-line chemotherapy).16 and 17 This platinum status classification is the primary covariate used in determining future prognosis and subsequent treatment strategies. However, as with most clinical covariates, its accuracy is not absolute; additional measures of platinum responsiveness may be beneficial in further personalizing treatment strategies. Using the current standard clinical approach, identification of platinum-resistant disease is delayed until after the patient has already experienced found the costs and toxicities associated with first-line therapy. Earlier identification of effective first-line treatment may improve the disease course in EOC patients, potentially allowing them to demonstrate response,

avoid recurrence for a longer time, and delay the onset of decline in overall health, thereby allowing more therapies to be given that may further extend OS. Unfortunately, molecular characterization of EOC has not yet been able to substitute for the clinically observed platinum status classification. The current study evaluates the potential utility of a chemoresponse assay in identifying platinum resistance in advanced-stage EOC patients undergoing standard first-line treatment. Determining platinum status earlier in the treatment of advanced-stage EOC may prevent this high-risk group of patients from being exposed to multiple cycles of ineffective therapy and allow for more effective alternate therapeutic options earlier in the disease, with the ultimate goal of improving patient outcomes.