The data support the view that the microtubule cytoskeleton is a valid therapeutic target in AD. Copyright (C) 2011 S. Karger AG, Basel”
“Esparto (Stipa tenacissima) is a highly fibrous herbaceous plant. In addition, the fiber properties (suppleness, thinness, and cellulose content) make this plant a valuable raw material for papermaking in terms of both quality and quantity. In Tunisia, esparto is the only source of
raw material for papermaking. In this paper, the chemical characteristics (cellulose, hemicelluloses, lignin, extractives, and ashes) of esparto leaves are analyzed in relation to growing conditions and plant biology. Four localized sites in the Kasserine region (central Tunisia) selleck are examined. The chemical properties of esparto fibers INCB024360 vary significantly with site and season. In fall, esparto leaves contain more cellulose (46.4%) than in other seasons. In winter, esparto leaves have lower cellulose content (43.3%) and higher extractive content. The pulp properties across seasons indicate that pulp yield and strength properties are superior when leaves are harvested in fall. (C) 2012 Elsevier B.V.
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“Objective: (1) To describe a case of necrotizing group A streptococcal periorbital infection in a patient receiving treatment with adalimumab (Humira, Abbott)-a fully humanized monoclonal anti-TNF-alpha agent. (2) To identify bacterial species responsible for infection with different forms of biological therapy.
Design:
Single interventional case report and literature review.
Case: A 57-year-old woman developed severe right-sided necrotizing periorbital infection whilst receiving treatment with adalimumab for rheumatoid arthritis (RA). Cultures grew Lancefield Group A Streptococcus pyogenes. An extensive literature search for reports of ocular infections associated with biological therapy was conducted.
Results: Dinaciclib cell line Adalimumab therapy was discontinued and the patient was admitted to an intensive care unit. The patient made a complete recovery after receiving appropriate antibiotic therapy. Overall Gram-positive cocci are the most common infection associated with use of biological therapy.
Conclusions: Anti-TNF-alpha agents are powerful immune-modulating drugs with potentially serious side effects. This case is the first to link adalimumab to necrotizing periorbital infection. Resolved infection does not preclude reintroduction of anti-TNF therapy however, careful assessment of the risks versus benefits of therapy is required at the individual patient level.”
“Background
Late occurrence of cytomegalovirus (CMV) infection remains a concern in CMV-seronegative kidney and/or pancreas transplant recipients of CMV-seropositive organs (donor positive/recipient negative, D+/R-) despite the use of prophylaxis. We investigated the impact of various antibody induction regimens on CMV infection in this group of patients.