The results for all these outcomes conclusively indicate no therapeutic benefit from dynamic splints. Of course, the interpretation of these results Libraries relies on the definition of a sufficiently important treatment effect. We articulated a sufficiently important treatment effect

for each outcome prior to commencement of the study based on clinical judgement and the recommendations of others. These were set at 10 degrees for all active wrist movements and 2 points for the two COPM items. Some may argue that we set these too high in which case the interpretation of our results would differ and leave open the possibility of detecting a treatment effect Selleck PD0332991 with a larger sample. Others may argue that wrist extension should not have been the primary outcome but instead PRHWE. We nominated wrist extension as our primary outcome because we were concerned about power and reasoned that splints could not be expected to change more meaningful measures of activity limitation or participations restrictions without an underlying change in wrist extension. As it turned out these concerns were unfounded and our measures of PRHWE had greater precision than our measures of wrist extension. Our failure to demonstrate a treatment effect may also have been due to poor compliance with the splinting regimen. Participants Anti-cancer Compound Library clinical trial were instructed to wear

the splint for at least 6 hours a day. It was difficult to attain accurate data on how often the splints were worn. However, our however best estimate suggests that most participants did not wear the splints for 6 hours a day. Nonetheless, adherence reflects the realities of wearing splints and was probably better than could be expected in clinical practice especially as we regularly reviewed participants and instructed them to record adherence in diaries. Perhaps the results would have

been different if the participants had worn the splints for more than 6 hours a day and/or more than 8 weeks. However, participants are unlikely to tolerate wearing splints for longer periods of time. For example, some disliked the look of the splints and others complained about the limitations the splints imposed on day-to-day activities. Alternatively, it is possible that the splints were ineffective because they did not provide a sufficient stretch. We do not know precisely how much stretch was applied but the splints were adjusted regularly to ensure they pulled the wrist into as much wrist extension as tolerated. This mimics current clinical practice and it is unlikely participants would have tolerated more stretch. Interestingly, all participants showed improvements in all outcomes over time. While it is tempting to interpret these findings as evidence of the effectiveness of the advice and home exercise program given to all participants and/or evidence about the good typical recovery following wrist fractures, neither interpretation is valid.