This assay could also be used to characterize rapidly the role and function of any novel Arabidopsis circadian mutant.”
“Twenty Baylis-Hillman adducts were synthesized from different aromatic aldehydes and activated vinyl derivatives. The adducts, which
are differently substituted 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives, were screened for their antimicrobial activity in vitro by the serial dilution method. Many of these molecules displayed potent antibacterial and antifungal activities. The ease of synthesis from low-cost starting materials along with potent antimicrobial activity of these molecules provide the lead for further improvement of Selleckchem CT99021 activity and reflect the possibility of therapeutic use.”
“Objectives: Standard therapies against inflammatory rheumatic diseases consist of immunosuppressive drugs with high toxicities and many side-effects. Except in the treatment of systemic lupus
erythematosus with renal involvement, controlled studies with mycophenolate mofetil (MMF) are lacking in other autoimmune and inflammatory systemic diseases. Here we describe our clinical experience with MMF in several unusual indications.
Methods: We collected data including serological findings, adverse events and response to treatment in eleven patients with autoimmune diseases including systemic JQ-EZ-05 mw lupus erythematosus (SLE), mixed connective tissue disease (MCTD), polymyositis SYN-117 concentration (PM), diffuse systemic sclerosis that were treated in our rheumatology unit.
Results: Our results show remission in ten patients with minimal side effects and reduced prednisone dosage. The median dose
of MMF was 2 g per day. Adverse events were limited, with one case of leucopenia, one tachycardia and one colitis. One patient definitively stopped the treatment because of side effects.
Conclusions: MMF seems to be a very powerful and attractive alternative medication in the treatment of immune-mediated inflammatory diseases. The good tolerance and safety profile makes it an excellent therapeutic option permiting a global reduction of corticosteroids doses.”
“P>Extracellular ATP regulates higher plant growth and adaptation. The signalling events may be unique to higher plants, as they lack animal purinoceptor homologues. Although it is known that plant cytosolic free Ca2+ can be elevated by extracellular ATP, the mechanism is unknown. Here, we have studied roots of Arabidopsis thaliana to determine the events that lead to the transcriptional stress response evoked by extracellular ATP. Root cell protoplasts were used to demonstrate that signalling to elevate cytosolic free Ca2+ is determined by ATP perception at the plasma membrane, and not at the cell wall.