However, the NTAGI has the ability to invite or co-opt experts in specific fields according to need and the topics to be discussed. Manufacturers of vaccines do not play any role in NTAGI but have been invited on occasion. The decisions (resolutions) and recommendations of the NTAGI are reached by general agreement among members and Chair and to date there has been no need for members to vote. On an ad hoc basis, NTAGI sub-groups and Expert Antidiabetic Compound Library Advisory Groups (outside NTAGI) are constituted through the Secretariat

to address specific issues and to submit their summary assessments, suggestions and recommendations. In addition, the existing disease-specific working groups on inhibitors measles and polio established through ‘Partner Networks’ (WHO, UNICEF, and other bilateral/international agencies) may forward their recommendations to the NTAGI for consideration. For recommendations regarding the introduction of a new vaccine into the UIP, the NTAGI may directly make resolutions, or assign the task to a Sub-group to bring its proposals to the NTAGI meeting. The decision-making process is based on disease HIF-1 activation epidemiology, disease burden, cost-effectiveness analyses and priority of vaccine introduction related

to other public health interventions. When data are inadequate, the opinions of experts and the collective wisdom of the members PD184352 (CI-1040) may be applied. Since its formation

in August 2001, the NTAGI has met six times (December 2001, October 2004, March 2006, July 2007, June 2008 and August 2009). A number of important interventions, namely introduction of vaccines against Japanese encephalitis, hepatitis B, rubella (in combination with a second opportunity for measles vaccine, as measles rubella vaccine) and Haemophilus influenzae type b (as a combination pentavalent vaccine) and introduction of auto-disable syringes in the UIP, were recommended by the NTAGI and have been accepted by the MoHFW [2]. More recently the NTAGI has made extensive deliberations on several issues—development of a Multi-Year Strategic Plan for the UIP (GoI, 2002–2007), the pros and cons of introduction of rotavirus and pneumococcal vaccines, enhanced measles control activities, the safety of thiomersal in vaccines, introduction of vaccine vial monitors on all vaccine vials, review of the human resource needs for immunisation at GoI and State levels and the re-engineering of the UIP as a system. For several issues the NTAGI has made specific recommendations, many of which have been acted on by the MoHFW. On some issues, the recommendations are still being considered. Over the years, the role of the NTAGI (and consequently the membership) has evolved to meet the changing requirements at the national level.